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| Product Name | Clostridium difficile Toxin B, Recombinant |
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| Description | Purity ~95% (SDS-PAGE shows a band between 60-65kD under reducing conditions.) Endotoxin: <1EU/ug (LAL). Clostridium difficile is the leading cause of hospital-acquired diarrhea, known as C. difficile-associated disease. The estimated number of cases of C. difficile-associated disease exceeds 250,000 per year (1), with health care costs approaching US $1 billion annually (2). The major virulence factors produced by C. difficile are two toxins, TcdA and TcdB. Both toxins can monoglucosylate and inactivate Rho family small GTPases within target cells, leading to disruption of vital signaling pathways in the cell, subsequently causing diarrhea, inflammation, and damage of colonic mucosa (3,4,5). Both toxins have a similar tripartite structure comprised of an N-terminal glucosyltransferase domain, a C-terminal receptor binding domain, and a small hydrophobic span possibly involved in toxin translocation (6). Our recombinant TcdB consists of the enzymatic domain. Both TcdA and TcdB also hav |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P18177 |
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| Catalog # | C5856-02 |
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| Order / More Info | Clostridium difficile Toxin B, Recombinant from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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