| 产品详情 |
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| Product Name | Sphingosine Kinase 1 Inhibitor, SKI-178 |
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| Description | Purity ~92% (HPLC). A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >> 25uM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8uM). Solubility: DMSO Molar Mass: 394.4 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Sphingosine Kinase 1 Inhibitor, SKI-178 (N'-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217804 |
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| Order / More Info | Sphingosine Kinase 1 Inhibitor, SKI-178 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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