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| Product Name | Interferon alpha, beta Receptor Chain 2, Fc Chimera, Recombinant, Human (IFNabR2) |
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| Description | Purity ~ 95%, as determined by SDS-PAGE and visualized by silver stain. Endotoxin: ≤.0 EU/ug (LAL). IFN-a/b R2, also known as IFNAR2, is a 100 kD glycoprotein in the class II cytokine receptor family. These proteins form heterodimeric receptor complexes that transduce signals from the interferon, IL-10, and IL-28 families of cytokines. 1,2 IFN-a/b R2, in association with IFN-a/b R1, is required for mediating the antiviral, antiproliferative, and apoptotic effects of the type I interferons IFN-a and IFN-b. IFN-a/b R2 is the principal ligand binding subunit of the receptor. Ligand binding is stabilized by the subsequent association with IFN-a/b R1, resulting in the formation of a signaling ternary receptor complex. Mature human IFN-a/b R2 consists of a 217 aa extracellular domain (ECD) with two fibronectin type III repeats, a 21aa transmembrane segment, and a 251aa cytoplasmic domain. Alternate splicing generates a secreted isoform that corresponds to the ECD and a 50kD transmembrane iso |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 3455, SwissProt: P48551 |
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| Catalog # | I7662-08C |
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| Order / More Info | Interferon alpha, beta Receptor Chain 2, Fc Chimera, Recombinant, Human (IFNabR2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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