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| Product Name | Hydroxysteroid Dehydrogenase, 11-beta, Type I (11b-HSD1) Control Peptide |
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| Description | Highly purified. Control peptide for H9117-60(antiserum) and H9117-65 (affintity purified antibody). Synthetic peptide corresponding to 16aa of mouse 11b-HSD1 conjugated to KLH. Species sequence homology: 100% conserved in the mouse and rat, 87% in sheep and 81% in human and chicken, 75% in porcine and 68% in rabbit 11b-HSD1. No significant sequence homology is seen with other proteins. 11-Beta-hydroxysteroid dehydrogenase (11b-HSD) is a microsomal short chain dehydrogenase/reductase (SDR) which catalyzes the inter-conversion of biologically active glucocorticoid (cortisol in human and corticosterone in rats and mice) and inactive glucocorticoid (cortisone and 11-dehydrocorticosterone). Two tissue specific isoforms (11b-HSD1 and 11b-HSD2) of 11b-HSD with two different functions regarding glucocorticoid availability, have been identified. The decreased 11-beta-hydroxy oxidation of cortisol results in Apparent Mineralocorticoid Excess (AME) disorder which is manifested by hypertension, h |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | H9117-70 |
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| Order / More Info | Hydroxysteroid Dehydrogenase, 11-beta, Type I (11b-HSD1) Control Peptide from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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