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| Product Name | XMD8-92 |
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| Description | Purity >98%. XMD8-92 is an ERK5 inhibitor (Kd = 80 nM) that less potently inhibits DCAMKL2, TNK1, and Plk4 (Kd s = 190, 890, and 600 nM, respectively), from a panel of 402 different tested kinases. It blocks ERK5 autophosphorylation, ERK5-mediated phosphorylation of promyelocytic leukemia protein (PML), and PML-dependent activation of p21. XMD8-92 suppresses tumor cell proliferation in vitro and tumor growth and angiogenesis in vivo . XMD8-92 inhibits AP-1 transcriptional activity induced by MEK5-activated ERK5 but not that induced by Cdc37. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one |
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| Gene, Accession, CAS # | CAS: 1234480-50-2 |
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| Catalog # | LS-H10533 |
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| Price | |
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| Order / More Info | XMD8-92 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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