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| Product Name | TPOR/MPL BioAssay™ ELISA Kit (Mouse) |
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| Description | The thrombopoietin receptor (TPOR), also known as CD110, is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene. The human MPL gene is mapped to chromosome 1p34. The protein encoded by the c-mpl gene, CD110, is a 635aa transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. Sample Type: Cell lysates, cell culture supernates, serum, plasma (EDTA or Heparin) Intended Use: Sandwich High Sensitivity BioAssay™ ELISA kit for Quantitative Detection of Mouse TPOR/MPL. Sensitivity: <15pg/ml Range: 156pg/ml-10,0 |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q08351 |
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| Catalog # | 396805 |
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| Order / More Info | TPOR/MPL BioAssay™ ELISA Kit (Mouse) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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