| 产品详情 |
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| Product Name | Rho Inhibitor II, Y16 |
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| Description | Purity ~95% (HPLC). A cell-permeable pyrazolidinedione compound that is shown to target RhoGEF DH-PH domain junction with high affinity (Kd = 65nM) and effetively prevent RhoGEFs LARG, p115, and PDZ from interacting with RhoA, while displaying little potency against DBL-RhoA, LBC-RhoA, intersectin-Cdc42, or TrioN-Cdc42 interaction. Shown to completely prevent serum-induced activation of cellular RhoA, but not Cdc42 or Rac1, in NIH-3T3 cultures (10uM) and RhoA downstream signaling events. Greatly synergizes with Rho GEF-binding domain blocker Rhosin in blocking RhoA-LARG interaction and in preventing cellular RhoA activation (both drug at 5uM). Synonyms: LARG Rho-Binding Domain Blocker, (E)-4-(3-(3-Methylbenzyloxy)benzylidene)-1-phenylpyrazolidine-3,5-dione, (4E)-4-(3-(3-Methylbenzyloxy)benzylidene)-1-phenyl-3,5-pyrazolidinedione, p115 Rho-Binding Domain Blocker, PDZ Rho-Binding Domain Blocker |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Rho Inhibitor II, Y16 (PDZ Rho-Binding Domain Blocker, LARG Rho-Binding Domain Blocker, (E)-4-(3-(3-Methylbenzyloxy)benzylidene)-1-phenylpyrazolidine-3,5-dione, (4E)-4-(3-(3-Methylbenzyloxy)benzylidene)-1-phenyl-3,5-pyrazolidinedione, p115 Rho-Binding Domain Blocker) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217743 |
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| Price | |
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| Order / More Info | Rho Inhibitor II, Y16 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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