| 产品详情 |
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| Product Name | Rho Inhibitor, Rhosin |
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| Description | Purity ~94% (HPLC). A cell-permeable (quinoxalinylmethylidene-D-Tryptophanyl)hydrazide that directly targets Rho GEF binding domain (Kd = 354nM for RhoA), thereby prevents Rho from interacting with its GEFs (including LARG, DBL, LBC, p115 RhoGEF, and PDZ RhoGEF), but not p190RhoGAP, RhoGDI, or its effectors (ROCK, mDia, PKN, Rhoteckin). Shown to inhibit serum-induced RhoA, RhoB, and RhoC, but not Cdc42 or Rac1, activation, MLC & PAK phosphorylation, as well as stress fiber & focal complex formation in serum-starved NIH3T3 cultures (Effective conc. 30uM) in a reversible manner. Primary Target: Rho GTPase Primary Target Ki: 354nM for RhoA Molar Mass: 358.4 Solubility: DMSO |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Rho Inhibitor, Rhosin ((2R)-2-Amino-3-(1H-indol-3-yl)-N'-((1E)-quinoxalin-6-ylmethylidene)propanehydrazide, G04) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217744 |
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| Price | |
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| Order / More Info | Rho Inhibitor, Rhosin from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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