| 产品详情 |
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| Product Name | Rho Kinase Inhibitor XIII, RKI-1447 |
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| Description | Purity ~98% (HPLC). A cell-permeable pyridylthiazolyl-urea that acts as a potent, ATP site-targeting, Rho Kinase inhibitor (IC50 = 14.5 and 6.2nM against ROCK1 and ROCK2, respectively), displaying much reduced potency against PKA, PKN1/PRK1, p70S6K/RPS6kB1, AKT1, MRCKa/CDC42BPA (85.5%, 80.5%, 61.9%, 56.0%, and 50.4% inhibition, respectively, by 1uM RKI-1447) or 15 other kinases. Selectively inhibits ROCK-dependent, but not mTORC2-dependent, cellular phosphorylations (effective conc. 0.1 to 1uM in MDA-MB-231, MDA-MB-468, and H1299 cultures). Shown to be efficacious in suppressing established tumor expansion in a murine ErbB2 mammary cancer model (200mg/kg/day i.p.) in vivo. Solubility: DMSO Primary Target: Rho kinases 1 & 2 Primary Target IC50: 14.5 and 6.2 nM against ROCK1 and ROCK2, respectively. Molar Mass: 422.5 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Rho Kinase Inhibitor XIII, RKI-1447 (1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea, Mesylate, 1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea, Methanesulfonate, ROCK Inhibitor XIII) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217745 |
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| Order / More Info | Rho Kinase Inhibitor XIII, RKI-1447 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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