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| Product Name | Mer RTK Inhibitor, UNC569 |
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| Description | Purity ~95% (HPLC). An orally bioavailable pyrazolopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of Mer receptor tyrosine kinase (IC50=2.9nM; Ki=4.3nM) with ~10-fold greater selectivity over other TAM family kinases (IC50=37 and 48nM for Axl and Tyro3, respectively). Also shown to affect the activities of Flt3, MAPKAPK2, RET and Ret-Y791F at 30nM by 82%, 92%, 59% and 56% in a 72 kinase panel, and block Mer auto-phosphorylation in human Pre-B leukemia 697 cells with an IC50 of 141nM. Exhibits desirable pharmacokinetic profile and efficacy in mice. Formula: C22H29FN6 Molecular Weight: 396.5 Solubility: DMSO (100mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Mer RTK Inhibitor, UNC569 (1-((trans-4-Aminocyclohexyl)methyl)-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine, MERTK Inhibitor I, RP38 Inhibitor I, TAM Family RTK Inhibitor I) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217542 |
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| Order / More Info | Mer RTK Inhibitor, UNC569 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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