| 产品详情 |
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| Antigenic Specificity | IVL / Involucrin |
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| Clone | SY5 |
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| Host Species | Mouse |
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| Reactive Species | dog, porcine, human, monkey |
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| Isotype | IgG1 |
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| Format | Protein A purified |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA, IHC, IHC-Fr, IHC-P (10 µg/ml), IP, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | IVL / Involucrin Antibody (clone SY5) IHC-plus™ LS-B6298. Recognizes human involucrin, a 585 amino acid soluble protein encoded by the IVL gene and expressed in epidermal keratinocytes as they tend towards terminal differentiation. Involucrin is produced in the stratum spinosum initially in the cell cytosol from where it moves to the cell membrane, associates with transglutaminase and becomes cross-linked to membrane proteins, offering structural support to the cell and forming a stable envelope below the plasma membrane. Recognizes an epitope between residues 421-568 of human involucrin. Involucrin expression is seen in the normal granular cells of the epidermis associated with the plasma membrane during the early phase of cornified envelope maturation and expression is increased in psoriatic epidermis with abnormal cornified envelope maturation. Involucrin staining is also maintained, associated with the cornified envelope in epidermolytic hyperkeratosis, a condition associated with mutations to mutations in genes coding for cytokeratins 1 and 10. Does not react with: Mouse |
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| Immunogen | Native, from keratinocytes. |
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| Other Names | IVL, Involucrin |
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| Gene, Accession # | IVL, Gene ID: 3713 |
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| Catalog # | LS-B6298 |
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| Price | |
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| Order / More Info | IVL / Involucrin Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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