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| Product Name | PRKDC, Recombinant, Mouse, aa3747-4015, His-Tag (DNA-dependent Protein Kinase Catalytic Subunit) |
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| Description | Purity ~90% (SDS-PAGE). Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | p460 |
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| Gene, Accession, CAS # | SwissProt: P97313 |
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| Catalog # | 374852 |
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| Order / More Info | PRKDC, Recombinant, Mouse, aa3747-4015, His-Tag (DNA-dependent Protein Kinase Catalytic Subunit) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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