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| Product Name | Recombinant Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2) Protein Vpx |
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| Description | 1-112aa; Full Length. MW: 28.81kD. Purity >90% as determined by SDS-PAGE. Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. I |
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| Size | 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.01 mg (Mammalian-Cell), 0.1 mg (E-Coli), 0.02 mg (Mammalian-Cell) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Viral protein X; X ORF protein] |
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| Gene, Accession, CAS # | vpx, Accession: P06939.1 |
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| Catalog # | MBS1114604 |
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| Order / More Info | Recombinant Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2) Protein Vpx from MYBIOSOURCE INC. |
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| Product Specific References | Identification of the nuclear localization signal of human immunodeficiency virus type 2 Vpx.Belshan M., Ratner L.Virology 311:7-15(2003) |
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