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| Product Name | Leptin Receptor B, Mouse, phosphorylated, (Tyr985) (ObRb, Obese Receptor B) (Control Peptide) |
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| Description | Highly purified. Obesity, a common nutritional disorder, is associated with diabetes, hypertension, hyperlipidemia, cancer and many other health related problems. Obese gene, leptin, mediates its effects via the Leptin receptor or obese receptors (OBR or LR) that is expressed in several tissues including hypothalamus. The OBR has at least 6 alternatively spliced forms (OBRa-f or LRa-f) that contain a common extracellular domain. OBRb or long isoform contains a unique ~ 300 aa long cytoplasmic tail that is required for leptin signaling. OBR is abnormally spliced (truncation of cytoplasmic domain) in db/db mice resulting into severe obesity. Leptin is structurally related to cytokine family and it activates cytokine-like signal transduction by stimulating the JAK-STAT pathway via the OBRb, a member of IL-6 receptor family of class I cytokine receptors. Leptin binding to OBRb results in the activation of JAK2 and subsequent phosphorylation of specific tyrosines (Tyr985 and Tyr1138) locate |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | L1671-12C |
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| Order / More Info | Leptin Receptor B, Mouse, phosphorylated, (Tyr985) (ObRb, Obese Receptor B) (Control Peptide) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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