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| Product Name | Leptin Receptor, Fc Chimera, Recombinant, Mouse (B219, CD295, LEPR, OB R) |
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| Description | Purity ~90% (SDS-PAGE). The Leptin receptor (Leptin R; gene name LEPR), also called OB R (obesity receptor), is a 150kD protein that is a member of the Class I cytokine receptor family. It mediates the activities of Leptin, a multifunctional hormone produced primarily by adipose tissues that plays roles in food intake, energy metabolism, angiogenesis, reproduction, hematopoiesis, bone metabolism, and immune function (13). The mouse Leptin R gene encodes 1162 amino acids (aa) including a signal peptide, an extracellular region with cytokine receptor homology (CRH), multiple fibronectin type III domains and a WSXWS motif, a transmembrane domain, and a cytoplasmic domain that supports JAK/STAT signaling (2, 3). Mouse Leptin R shares 93% aa sequence identity with rat Leptin R and 74-76% with human, bovine, canine, equine and porcine Leptin R. Leptin R isoforms include a long form, OB RL or OB Rb (primary signaling form), and at least four shorter isoforms with truncated cytoplasmic doma |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P48356 |
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| Catalog # | 145817 |
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| Order / More Info | Leptin Receptor, Fc Chimera, Recombinant, Mouse (B219, CD295, LEPR, OB R) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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