| 产品详情 |
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| Product Name | HAA,O, 1-286aa, Human, His tag, E.coli |
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| Description | Purity: > 90% by SDS - PAGE Format: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT. HAAO is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. This protein catalyzes the synthesis of quinolinic acid (QuIN) from 3-hydroxyanthranilic acid. QuIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QuIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QuIN. Recombinant human HAAO protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
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| Size | 250ug, 50ug, 10ug |
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| Concentration | n/a |
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| Applications | SDS-PAGE |
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| Other Names | 3-hydroxyanthranilate 34-dioxygenase, 3-hydroxyanthranilate 3,4-dioxygenase, 3-HAO, HAO |
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| Gene, Accession, CAS # | NP 036337 |
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| Catalog # | ATGP1559 |
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| Price | |
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| Order / More Info | HAA,O, 1-286aa, Human, His tag, E.coli from ATGen |
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| Product Specific References | n/a |
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