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| Product Name | LIFR, Recombinant, Mouse |
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| Description | Purity ~95% (SDS-PAGE, reducing conditions). Leukemia Inhibitory Factor Receptor alpha (LIF R-alpha), also known as LIFR beta and CD118, is a 190kD type I transmembrane protein in the Interleukin-6 receptor family. Members of this family mediate the biological effects of Cardiotrophin-1, CLC, CNTF, IL-6, IL-11, IL-27, and Oncostatin M. Mature mouse LIF R-alpha consists of a 785aa extracellular domain (ECD) with two cytokine receptor homology domains, one WSxWS motif, and three fibronectin type III repeats, followed by a 25aa transmembrane segment and a 239aa cytoplasmic domain. Within the ECD, mouse LIF R-alpha shares 73% and 90% aa sequence identity with human and rat LIF R-alpha, respectively. Alternative splicing generates a 90kD soluble form of the mouse LIF R-alpha ECD. LIF R-alpha binds the pleiotropic cytokine LIF with low affinity, and the soluble isoform retains LIF-binding activity. Binding affinity is increased by the ligand-induced association of LIF R-alpha with the signal |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | LIFR, Recombinant, Mouse (Leukemia Inhibitory Factor Receptor, LIF Receptor, LIF-R, D-factor/LIF Receptor, CD118) |
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| Gene, Accession, CAS # | SwissProt: P42703 |
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| Catalog # | L2024-03A |
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| Order / More Info | LIFR, Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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