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| Product Name | Glycoprotein V, Recombinant, Human (CD42d, GPV, Platelet glycoprotein V, GP5) |
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| Description | Purity ≥95% by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin: ≤1EU/ug (LAL). GPV (platelet glycoprotein V; designated CD42d) is an 83kD type I transmembrane (TM) glycoprotein of the leucine-rich repeat (LRR) family. It is expressed exclusively within the platelet/megakaryocyte lineage, where it noncovalently interacts with other platelet TM LRR proteins, GPIba/b and GPIX, at a rati o of one GPV to two of each other subunit. The GPI-V-IX complex tethers platelets to von Willebrand factor on the surface of injured endothelial cells. Absence of the complex results in Bernard-Soulier syndrome, a rare bleeding disorder. The human GPV cDNA encodes a 560aa protein with a 16aa signal sequence, a 507aa extracellular domain (ECD) containing 15 LRR, a 21aa TM sequence, and a short (16aa) cytoplasmic tail that binds calmodulin in resting, but not activated platelets. The human GPV ECD shares 70%, 71% and 81% aa identity with mouse, rat and equine GPV, respectively. G |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P40197 |
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| Catalog # | G4905 |
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| Order / More Info | Glycoprotein V, Recombinant, Human (CD42d, GPV, Platelet glycoprotein V, GP5) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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