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| Product Name | XL765 |
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| Description | Purity >95%. Phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) constitutively signal and drive cell survival and proliferation in many forms of cancer. XL765 is a dual inhibitor of both PI3K and mTOR, completely blocking phosphorylation of substrates at 8-16 µM. Similarly, XL765 is cytotoxic to glioblastoma multiforme (GBM) xenografts in vitro, with half maximal inhibition occurring at 3.7-7.7 µM. XL765 is orally bioavailable and passes the blood-brain barrier, reducing the growth of intracranial GBM xenografts in mice. This inhibitor is effective alone or in combination therapy with other compounds in various types of cancer. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[4-[[[3-[(3,5-dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methyl-benzamide, SAR245409, Voxtalisib |
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| Gene, Accession, CAS # | CAS: 1349796-36-6 |
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| Catalog # | LS-H10529 |
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| Price | |
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| Order / More Info | XL765 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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