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| Product Name | Caspase-3, Proform, Recombinant, Mouse |
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| Description | Purity ~90% (SDS-PAGE). Caspase-3 (also know as CPP32, Yama and apopain) is a member of the caspase family of cysteine proteases. Caspase-3 exists in cells as an inactive 32kD proenzyme. Proteolytic processing of this inactive proenzyme generates the 17kD and 12kD subunits which, when assembled as a tetramer (a pair of heterodimers), form the active caspase. Cascades of caspase activation have been shown to be key signal-transducing events in apoptosis. Procaspase-3, like other procaspases with short N-terminal prodomains, is considered to be a downstream or ``effector'' enzyme. Pro-caspase-3 can be cleaved and activated by caspase-8 and -10 which are themselves activated through interaction with death ligand receptor/adapter protein complexes (e.g., Fas/FADD). Procaspase-3 is also processed by caspase-9, the apical caspase that is activated by binding to the Apaf-1/cytochrome c/ATP ``apoptosome''. Thus, activation of procaspase-3 stands at a point of convergence for the two major types of |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Caspase-3, Proform, Recombinant, Mouse (Casp3, Apopain, Cysteine Protease CPP32, CPP-32, LICE, Protein Yama, SREBP Cleavage Activity 1, SCA-1, Cpp32) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 169638 |
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| Order / More Info | Caspase-3, Proform, Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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