| 产品详情 |
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| Product Name | 2-Arachidonoyl Glycerol |
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| Description | Purity >95%. 2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the cannabinoid (CB) receptors CB1 and CB2 (Ki s = 25.3-472 and 145-1,400 nM, respectively). Unlike arachidonoyl ethanolamide (AEA), 2-AG is present at relatively high levels in the central nervous system and is the most abundant molecular species of monoacylglycerol (MAG) found in rat brain. Formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C (PLC) and diacylglycerol (DAG) lipase. 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism. 2-AG is metabolized in vitro by MAG lipase and fatty acid amide hydrolase (FAAH), with MAG lipase likely being the principle metabolizing enzyme in vivo . |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5Z,8Z,11Z,14Z-eicosatetraenoic acid, 2-glyceryl ester, 2-AG |
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| Gene, Accession, CAS # | CAS: 53847-30-6 |
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| Catalog # | LS-H5973 |
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| Price | |
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| Order / More Info | 2-Arachidonoyl Glycerol from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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