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| Product Name | TIMP1, 24-207aa, Human, His tag, E.coli (Denatured) |
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| Description | Purity: > 90% by SDS - PAGE Format: Liquid, In 20mM Tris-HCl (pH8.0) containing 10% glycerol. TIMP1 also known as metalloproteinase inhibitor 1. The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitors of metalloproteinases (TIMPs), which comprise a family of four protease inhibitors: TIMP1, TIMP2, TIMP3 and TIMP4. Overall, all MMPs are inhibited by TIMPs once they are activated but the gelatinases (MMP-2 and MMP-9) can form complexes with TIMPs when the enzymes are in the latent form. The complex of latent MMP-2 (pro-MMP-2) with TIMP-2 serves to facilitate the activation of pro-MMP-2 at the cell surface by MT1-MMP (MMP-14), a membrane-anchored MMP. The role of the pro-MMP-9/TIMP-1 complex is still unknown. Recombinant human TIMP1, fused to His-tag at N-terminus, was expressed in E.coli. |
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| Size | 0.5mg, 100ug, 20ug |
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| Concentration | n/a |
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| Applications | SDS-PAGE |
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| Other Names | Metalloproteinase inhibitor 1, EPA, EPO, HCI, CLGI, TIMP |
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| Gene, Accession, CAS # | NP 003245 |
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| Catalog # | ATGP3013 |
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| Order / More Info | TIMP1, 24-207aa, Human, His tag, E.coli (Denatured) from ATGen |
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| Product Specific References | n/a |
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