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| Product Name | MMP7 / Matrilysin Protein (Recombinant) |
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| Description | Purity >95% by SDS-PAGE and RP-HPLC. Matrix metalloproteinase-7 (MMP-7) also known as matrilysin and PUMP (EC 3.4.24.23) cleaves a number of substrates including collagen types IV and X, elastin, fibronectin, gelatin, laminin and proteoglycans. MMP-7 is closely related to the stromelysin family members but is encoded by a different gene. MMP-7 is the smallest of all the MMPs consisting of a pro-peptide domain and a catalytic domain. It lacks the hemopexin-like domain common to other members of the MMPs. MMP-7 is secreted as a 28 kDa proenzyme and can be activated in vitro by organomercurials and trypsin and in vivo by MMP-3 to a 18 kDa active MMP-7 enzyme. Once activated, MMP-7 can activate pro-MMP-1 and pro-MMP-9 but not pro-MMP-2. MMP-7 is widely expressed having been reported in elevated levels in cycling endometrium as well as in colorectal cancers and adenomas, hepatocellular carcinomas, rectal carcinomas, and approximately 50% of gliomas. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MMP7, Matrilysin, Matrin, MMP-7, MPSL1, PUMP-1, Pump-1 protease, MPMM, Uterine matrilysin, Punctuated metalloproteinase 1, Matrix metalloproteinase-7, PUMP1, Uterine metalloproteinase |
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| Gene, Accession, CAS # | MMP7, Gene ID: 4316 |
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| Catalog # | LS-G17492 |
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| Order / More Info | MMP7 / Matrilysin Protein (Recombinant) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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