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| Product Name | Frizzled-4, Recombinant, Human |
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| Description | Purity ≥95% (SDS-PAGE). Frizzled-4, designated CD344, is a 7-transmembrane glycoprotein of the Frizzled family within the G-protein coupled receptor superfamily. Frizzled proteins function as receptors for Wnt proteins and can activate canonical Wnt/beta-catenin signaling as well as planar cell polarity and calcium flux pathways. Frizzled-4 is particularly important in angiogenic Wnt pathway signaling. Frizzleds contain a divergent N-terminal signal peptide, a highly conserved ~120aa cysteine-rich domain (CRD), a variable length linker region, seven transmembrane domains, and a variable-length C-terminal tail. The human Frizzled-4 cDNA encodes 537aa with a 36aa signal sequence and a 186aa N-terminal extracellular sequence. The portion expressed in this product includes aa37-180, and shares 93%, 93%, 94%, 95% and 97% identity with the corresponding region of mouse, rat , bovine, canine and equine Frizzled-4, respectively. This portion competes for Wnt binding with endogenous receptors. |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Frizzled-4, Recombinant, Human (FZD4, CD344, EVR1, FEVR, Frizzled-4, Fz-4, FZD4S, FzE4, GPCR, hFz4, MGC34390) |
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| Gene, Accession, CAS # | SwissProt: Q9ULV1 |
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| Catalog # | F6401-14A |
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| Order / More Info | Frizzled-4, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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