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| Product Name | Frizzled-1, Recombinant, Human (FZD1) |
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| Description | Purity ~90%. Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Source: Recombinant protein corresponding to aa73-253 from human Frizzled-1, expressed in HEK293 cell expression system. Molecular Weight: ~46.4kD AA Sequence: QAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISVPDHGYCQPISIPLCTDIAY NQT |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | FZD1 |
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| Gene, Accession, CAS # | Accession: BC_051271 |
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| Catalog # | 172329 |
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| Order / More Info | Frizzled-1, Recombinant, Human (FZD1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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