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| Product Name | Frizzled-4, Recombinant, Human (FZD4) |
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| Description | Purity ~90%. Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-prot |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | FZD4 |
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| Gene, Accession, CAS # | Accession: BC_114527 |
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| Catalog # | 172331 |
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| Order / More Info | Frizzled-4, Recombinant, Human (FZD4) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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