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| Product Name | PLA2G4A, Recombinant, Human |
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| Description | Purity ~80% by SDS-PAGE under reducing conditions and visualized by silver stain and quantitative densitometry by Coomassie Blue stain Endotoxin: ≤1EU/1ug (LAL). Cytosolic Phospholipase A2a (PLA2G4A) belongs to the group IV phospholipase A2 family. These enzymes hydrolyze the ester bond at the second position (sn-2) of membrane glycerophospholipids. The group IV phospholipase A2 (PLA2G4) family is comprised of six intracellular enzymes. PLA2G4A has a preference for arachidonic acid in the sn-2 position of phospholipids indicating its involvement in the metabolism of eicosanoids. Its active site is characterized by a serine and aspartic acid dyad. The overall structural feature displays two domains, a lipid binding C2 domain and a catalytic a/b hydrolase domain. PLA2G4A translocation to the membrane and activation is facilitated by a calcium-ion dependent conformational change in its C2 domain. In addition, phosphorylation of serine residues in PLA2G4A by protein kinases may be another |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PLA2G4A, Recombinant, Human (Cytosolic Phospholipase A2, cPLA2, Phospholipase A2 Group IVA, Phospholipase A2, Phosphatidylcholine 2-acylhydrolase, Lysophospholipase, PLA2G4, CPLA2) |
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| Gene, Accession, CAS # | Accession: NP_077734, Gene ID: 5321 |
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| Catalog # | P4074-03R |
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| Order / More Info | PLA2G4A, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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