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| Product Name | Fibrinogen, Rabbit (Coagulation Factor I) |
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| Description | Purified by SPE extraction with immunoaffinity resins. The thrombin (IIa) catalyzed cleavage of soluble fibrinogen (Fbg) to form fibrin (Fbn) is the terminal proteolytic event in the coagulation cascade. These soluble Fbn monomers spontaneously polymerize to form an insoluble Fbn network which is stabilized by the factor XIIIa catalyzed crosslinking of lys and glu residues of a and g chains. This Fbn network is the major protein component of the hemostatic plug. Plasma fibrinogen is large glycoprotein (40kD) synthesized in the liver and circulating at a concentration of 2.6mg/ml. It is a disulfide linked dimer composed of 3 pairs of disulfide linked non-identical polypeptide chains (Aa, Bb and g). Notable features of the Aa chain are the N-terminal peptide (fibrinopeptide A (FPA, 1-16)), factor XIIIa crosslinking sites and 2 phosphorylation sites. When synthesized, Fbg is fully phosphorylated, but circulates at only 20-30% phosphorylation. The Bb chain contains fibrinopeptide B (FPB, 1 |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | F4215-37A |
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| Order / More Info | Fibrinogen, Rabbit (Coagulation Factor I) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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