| 产品详情 |
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| Antigenic Specificity | PDCD4 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 2.5 µg/mL, Western Blot: 0.5-1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PDCD4 Polyclonal Antibody. Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. During this process, the expression patterns of numerous genes are radically altered. One such gene is the programmed cell death protein 4 (PDCD4), whose expression was found to be upregulated in all cell lines following the onset of apoptosis. PDCD4 encodes a tumor suppressor protein whose expression is lost in carcinomas of breast, colon, lung and prostate. It can bind to and inhibit the helicase activity of the eukaryotic translation initiation factor 4A and inhibit the transactivation and transformation mediated by the transcription factor AP-1. The kinase Akt regulates PD |
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| Immunogen | n/a |
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| Other Names | RP11-348N5.4, H731; neoplastic transformation inhibitor protein; nuclear antigen H731; programmed cell death protein 4; protein 197/15a |
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| Gene, Accession # | Entrez: 18569, 27250, 64031; Uniprot: Q53EL6, Q61823, Q9JID1 |
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| Catalog # | PA5-20309 |
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| Price | |
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| Order / More Info | PDCD4 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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