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| Antigenic Specificity | Mitogen-Activated Protein Kinase 1 (MAPK1) (N-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 200 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many cellular programs such as cell proliferation, differentiation, motility, and death. The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines and is an important target in the diagnosis and treatment of cancer. Upon stimulation, a sequential three-part protein kinase cascade is initiated, consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). Multiple p44/42 MAP3Ks have been identified, including members of the Raf family, as well as Mos and Tpl2/Cot. MEK1 and MEK2 are the primary MAPKKs in this pathway. MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. Several downstream targets of p44/42 have been identified, including p90RSK and the transcription factor Elk-1. p44/42 are negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs , along with MEK inhibitors such as U0126 and PD98059.Synonyms: MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk |
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| Immunogen | N term peptide of human MAPK1 |
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| Other Names | ATMPK1|F14N23.9|F14N23_9|MITOGEN-ACTIVATED PROTEIN KINASE|mitogen-activated protein kinase 1|ATMPK2|MITOGEN-ACTIVATED PROTEIN KINASE HOMOLOG 2|T30E16.13|T30E16_13|mitogen-activated protein kinase homolog 2|ERK2|zERK2|MAPK1|ERK|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|9030612K14Rik|AA407128|AU018647|C78273|Erk2|Prkm1|p42mapk|erk|erk2|ert1|mapk|mpk1|xp42|mapk2|prkm1|prkm2|Xp42|mapk1b|mapk1|mapk1a |
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| Gene, Accession # | Gene ID: 5594,26413,50689 |
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| Catalog # | ABIN1514319 |
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| Price | |
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| Order / More Info | Mitogen-Activated Protein Kinase 1 (MAPK1) (N-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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