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| Product Name | CRM1 Inhibitor III |
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| Description | Purity ~95% (HPLC). A cell-permeable butenediamide compound that acts as a potent, active site cysteine reactive irreversible inhibitor of CRM1/exportin 1. Shown to selectively repress agonist-mediated nuclear export of HDAC4/5, Rev and NFAT proteins in neonatal rat ventricular myocytes (NRVMs; EC50=2.2 and 3.5nM for GFP-HDAC5 and GFP-HIV Rev) and suppress hypertrophic growth of NRVMs (EC50=52nM for ANF expression inhibition) with negligible effect either on the phosphorylation of HDAC5 or on the kinase activities of P and CaMKII at 1uM. Solubility: DMSO (100mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CRM1 Inhibitor III (Chromosome Region Maintenance 1 Protein Inhibitor III, (Z)-But-2-enedioic acid (4'-bromophenyl)amide (3''-chlorophenyl)amide, Exportin 1 Inhibitor III, XPO1 Inhibitor III) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217289 |
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| Price | |
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| Order / More Info | CRM1 Inhibitor III from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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| 产品资料 |
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