| 产品详情 |
| Edit |   |
|---|
| Product Name | CRM1 Inhibitor IV, KPT-251 |
|---|
| Description | Purity ~99% (HPLC). A cell-permeable, irreversible, triazole-containing heterotricyclic CRM1 inhibitor that effectively blocks CRM1-mediated nuclear export (4h 1uM in U2OS cells) via covalent interaction with CRM1 NES- (nuclear export signal) binding groove cysteine (Cys528 in human). Exhibits antileukemic activity against primary human CD19+ CLL (IC50 <500nM) via apoptosis induction even in the presence of stroma cells or other known CLL survival stimuli, while exhibiting little cytotoxicity toward CD56+ NK cells from healthy donors (1uM; up to 72h). Reported to prolong the survival of SCID mice (75mg/kg p.o.) engrafted with murine E-mu-TCL1 or human MV4-11 leukemia in vivo. Solubility: DMSO Primary Target: XPO1 Molar Mass: 375.23 |
|---|
| Size | 5mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | CRM1 Inhibitor IV, KPT-251 (KPT251, (Z)-2-(2-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole, Exportin 1 Inhibitor IV, Chromosome Region Maintenance 1 Protein Inhibitor IV, CRM1 Inhibitor IV, XPO1 Inhibitor IV) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217290 |
|---|
| Price | |
|---|
| Order / More Info | CRM1 Inhibitor IV, KPT-251 from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|