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| Product Name | DDR1, Fc Chimera, Recombinant, Human |
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| Description | Purity > 85%, as determined by SDS-PAGE and visualized by silver stain. Endotoxin: < 1.0 EU per 1ug of protein as determined by the LAL method. DDR1, also known as CAK, CD167a, RTK6, and TrkE, is a 120-140kD type I transmembrane glycoprotein that belongs to the discoidin-like domain containing subfamily of receptor tyrosine kinases (1, 2). Mature human DDR2 consists of a 398 amino acid (aa) extracellular domain (ECD) that includes the discoidin-like domain, a 27 aa transmembrane segment, and a 470 aa cytoplasmic region with a tyrosine kinase domain (3). Within the ECD, human DDR1 shares 53% aa sequence identity with human DDR2 and 93% with mouse and rat DDR1. DDR1 is expressed on epithelial tissues, activated monocytes and neutrophils, and in several cancers (2, 4). Compared to isoform DDR1b, DDR1a lacks 37 aa's that include a Shc-interacting NPxY motif in the cytoplasmic juxtamembrane region (5). Two additional kinase deficient splice forms are expressed in colon cancer (6). The disco |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | DDR1, Fc Chimera, Recombinant, Human (Discoidin Domain Receptor 1, CAK, CD167, EC 2.7.10.1, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE) |
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| Gene, Accession, CAS # | Gene ID: 780, SwissProt: Q5ST11 |
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| Catalog # | D1649 |
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| Order / More Info | DDR1, Fc Chimera, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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