| 产品详情 |
| Edit |   |
|---|
| Product Name | Syk Inhibitor VI, R406 |
|---|
| Description | Purity ~99% (HPLC). A cell-permeable, orally bioavailable pyrimidinediamino compound with anti-inflammatory and anti-tumor properties. Acts as a potent, reversible and ATP-competitive inhibitor of Syk kinase (IC50 = 41nM; Ki = 30nM). Exhibits high selectivity over a broad panel of other protein kinases (?300nM), ion channels, and enzymes. Blocks Syk-dependent FcR-mediated activation of monocytes/macrophages, and neutrophils and inhibits Anti-IgE-mediated degranulation in cultured human mast cells (EC50 = 56nM as measured by tryptase release). At higher concentrations, it is shown to block adenosine A3 receptors, adenosine transporter, and monoamine transporter (IC50 = 81nM, 1.84uM, and 2.74uM, respectively), and Flt3 autophosphorylation. Shown to reduce immune complex-mediated inflammation in murine models (?10mg/kg) and diminish airway hyper-responsiveness in asthma models. Solubility: DMSO Primary Target: Syk kinase Primary Target Ki: 30nM |
|---|
| Size | 5mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Syk Inhibitor VI, R406 (N4-(2,2-Dimethyl-3-oxo-4H-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine, 6-(5-Fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217820 |
|---|
| Price | |
|---|
| Order / More Info | Syk Inhibitor VI, R406 from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|