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| Product Name | Erap1, Recombinant, Mouse, aa731-930, His-Tag (Endoplasmic Reticulum Aminopeptidase 1) |
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| Description | Purity ~90% (SDS-PAGE). Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney (By similarity). Source: Recombinant protein corresponding to aa731-930 from mouse Erap1, fused to His-Tag at N-terminal and Myc-Tag at C-terminal expressed in E.coli. Molecular Weight: ~28.3kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ARTS-1 Adipocyte-derived leucine aminopeptidase |
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| Gene, Accession, CAS # | SwissProt: Q9EQH2 |
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| Catalog # | 373209 |
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| Order / More Info | Erap1, Recombinant, Mouse, aa731-930, His-Tag (Endoplasmic Reticulum Aminopeptidase 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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