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| Product Name | PDE6B, Active |
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| Description | Full Length. MW: ~124 kDa. Description: Full-length recombinant human PDE6B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: PDE6B is a member of the phosphodiesterase family of proteins that play a critical role in regulating intracellular levels of cAMP and cGMP. PDE6B is a high-affinity cGMP-specific PDE that shows high expression in the eye. Four mutations in the PDE6B gene lead to a degenerative disease of photoreceptors called retiniti |
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| Size | 0.005 mg, 0.01 mg |
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| Concentration | n/a |
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| Applications | PDE Assay |
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| Other Names | [Homo sapiens phosphodiesterase 6B (PDE6B), transcript variant 1, mRNA; Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; phosphodiesterase 6B] |
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| Gene, Accession, CAS # | PDE6B, Gene ID: 5158, Accession: NM_000283.3 |
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| Catalog # | MBS515636 |
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| Order / More Info | PDE6B, Active from MYBIOSOURCE INC. |
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| Product Specific References | 1. McLaughlin M E, et al: Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase in patients with retinitis pigmentosa. Nat Genet. 1993 Jun;4 (2):130-4. 2. Bennett J, et al: Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy. Nature Med. 2: 649, 1996. |
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