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| Product Name | Apoptosis Inducing Factor, Mouse, Control Peptide (AIF) |
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| Description | Highly purified. Control Peptide for A1059-80A (antiserum) and A1059-80 (affinity purified) 20-aa peptide from mouse AIF. Mitochondria play a pivotal role in the regulation of programmed cell death or apoptosis. Apoptosis is driven by two classes of specialized proteases known as caspases (Cysteine aspartase). The initiator caspases can be activated by self-cleavage. The effector caspases are then activated in an amplification cascade. Several key participants are released from the mitochondria that regulate apoptosis. The first such factor (Cytochrome-C) to be described binds to a cytoplasmic scaffolding protein called Apaf-1. Binding of the mitochondria factor allows Apaf-1 to form a ternary complex with, and activate, the initiator pro-caspase-9. Active caspase-9 then turns on downstream effector caspases, initiating apoptosis. Another mitochondrial-derived factor, termed Apoptosis inducing factor (AIF), has been identified. AIF is sufficient to induce apoptosis of isolated nuclei. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | A0906-92C |
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| Order / More Info | Apoptosis Inducing Factor, Mouse, Control Peptide (AIF) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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