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| Product Name | Apo-SAA, Recombinant, Human |
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| Description | Purity ≥98% by SDS-PAGE gel and HPLC analyses. Human apo-SAA is a 104 amino acid polypeptide that circulates primarily in association with high-density lipoproteins (HDL). The level of apo-SAA, normally 1-5 mug/ml in plasma, increases 500-1000 fold within 24 hours of an inflammatory stimulus and, under these conditions, is the most abundant HDL apo-lipoprotein.The human SAA gene codes for a 122 amino acid polypeptide, which contains an 18 amino acid N-terminal signal sequence.Recombinant Apo-SAA is a consensus SAA molecule corresponding to human apo-SAA1alpha except for the presence of an N-terminal methionine and substitution of asparagine for aspartic acid at position 60 and arginine for histidine at position 71(the latter two substituted residues are present in apo-SAA2beta). Biological Activity: Tested by its ability to down-regulate lipid biosynthesis in aortic smooth muscle cells. The effective concentration was found to be 4uM. Schreiber, BM. et al. Biochem J. 1999 Nov 15; 344 P |
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| Size | 10ug, 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 143282 |
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| Order / More Info | Apo-SAA, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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