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| Product Name | CD278, Recombinant, Human, aa21-139 |
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| Description | Purity ~98% (SDS-PAGE). CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. Source: Recombinant protein corresponding to aa21-139 from human CD278, fused to the N-terminus of the Fc region of mouse IgG2a, expressed in CHO cells. Biological Activity: Measured by its ability to inhibit human T cell proliferation induced by CD275 in the presence of anti-CD3. Endotoxin: ~0.06EU/ug protein (LAL test; Lonza) |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CD278, Recombinant, Human, aa21-139 (ICOS, Inducible T Cell Costimulator, CRP1, CD28-related Protein-1, AILIM) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 207111 |
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| Order / More Info | CD278, Recombinant, Human, aa21-139 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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