| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (Extracellular) |
|---|
| Clone | CB3-1 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG1 |
|---|
| Format | fluorescein (FITC) conjugate |
|---|
| Size | 100 tests |
|---|
| Concentration | n/a |
|---|
| Applications | Flow Cytometry (FACS),Immunoprecipitation (IP),Western Blotting (WB) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling. |
|---|
| Immunogen | Fraction of Ig-associated molecules isolated from Ramos B cells |
|---|
| Other Names | B29|Ig-beta|Igb|Igbeta|AGM6|IGB |
|---|
| Gene, Accession # | Gene ID: 974 |
|---|
| Catalog # | ABIN1027695 |
|---|
| Price | |
|---|
| Order / More Info | CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (Extracellular) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | PubMed: 10800181, 11896067, 19633198, 10753858, 19808977, 1382292 |
|---|
| 产品资料 |
|
|