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| Antigenic Specificity | CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (Extracellular) |
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| Clone | CB3-1 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | phycoerythrin (PE) conjugate |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS),Immunoprecipitation (IP),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling. |
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| Immunogen | Fraction of Ig-associated molecules isolated from Ramos B cells |
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| Other Names | B29|Ig-beta|Igb|Igbeta|AGM6|IGB |
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| Gene, Accession # | Gene ID: 974 |
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| Catalog # | ABIN1027696 |
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| Order / More Info | CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (Extracellular) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 10800181, 11896067, 19633198, 10753858, 19808977, 1382292 |
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