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| Product Name | FIP1L1-PDGFR alpha Mutant, Active |
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| Description | 1-265 (FIP1L1). MW: 130 kDa. Description: Recombinant human FIP1L1-PDGFRA, the fusion protein [FIP1L1 (1-265)-PDGFRA (579-end)], was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: FIP1L1 or factor interacting with PAPOLA and CPSF1 is a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase t |
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| Size | 0.005 mg, 0.01 mg |
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| Concentration | n/a |
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| Applications | Kinase Assay |
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| Other Names | [Synthetic construct Homo sapiens clone IMAGE:100001645 for hypothetical protein (FIP1L1 gene)] |
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| Gene, Accession, CAS # | FIP1L1-PDGFR alpha, Accession: AM392758 |
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| Catalog # | MBS515568 |
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| Order / More Info | FIP1L1-PDGFR alpha Mutant, Active from MYBIOSOURCE INC. |
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| Product Specific References | 1. Cools, J. et.al: A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. New Eng. J. Med. 348: 1201-1214, 2003. 2. Stover, E. H. et.al: FIP1L1-PDGFR-alpha requires disruption of the juxtamembrane protein of PDGFR-alpha and is FIP1L1-independent. Proc. Nat. Acad. Sci. 103: 8078-8083, 2006. |
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