| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | Lysine (K)-Specific Demethylase 1A (KDM1A) |
|---|
| Clone | 1E5-H2 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG1 |
|---|
| Format | affinity purified |
|---|
| Size | 100 µL |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blotting (WB),Immunocytochemistry (ICC),Immunoprecipitation (IP) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | This gene encodes a nuclear protein containing a SWIRM domain,a FAD-binding motif,and an amine oxidase domain. This protein is a component of several histone deacetylase complexes,though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq,Apr 2009]Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3,thereby acting as a coactivator or a corepressor,depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me,a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone,it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription,by being recruited to ANDR target genes and mediating demethylation of H3K9me,a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes,which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph),a specific tag that prevents demethylation H3K4me,prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses,via histone deacetylase (HDAC) recruitment,a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1,CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7. Subunit structure: Component of a RCOR/GFI/KDM1A/HDAC complex. Interacts directly with GFI1 and GFI1B by similarity. Component of a BHC histone deacetylase complex that contains HDAC1,HDAC2,HMG20B,KDM1A,RCOR1 and PHF21A. The BHC complex may also contain ZMYM2,ZNF217,ZMYM3,GSE1 and GTF2I. In the complex,RCOR1/CoREST strongly enhances the demethylase activity and protects it from the proteasome while PHF21A/BHC80 inhibits the demethylase activity. Interacts with the androgen receptor (AR). Interacts with ASXL1. Interacts with SNAI1 (via SNAG domain). Subcellular location: NucleusSequence similarities: Belongs to the flavin monoamine oxidase family. Contains 1 SWIRM domain. |
|---|
| Immunogen | Purified recombinant human KDM1/LSD1 protein fragments expressed in E.coli. |
|---|
| Other Names | KDM1|AOF2|KDM1A|DKFZp459N2450|aof2|kdm1|lsd1|xLSD1|BHC110|LSD1|1810043O07Rik|AA408884|Aof2|D4Ertd478e|Kdm1|Lsd1|mKIAA0601|RGD1562975|wu:fb82e06|wu:fc51a02|wu:fj36a05|wu:fj66b06|ARABIDOPSIS LYSINE-SPECIFIC HISTONE DEMETHYLASE|ATLSD1|ATSWP1|F23N19.21|F23N19_21|LSD1-like 1|LYSINE-SPECIFIC HISTONE DEMETHYLASE|SWP1 |
|---|
| Gene, Accession # | Gene ID: 23028 |
|---|
| Catalog # | ABIN2169542 |
|---|
| Price | |
|---|
| Order / More Info | Lysine (K)-Specific Demethylase 1A (KDM1A) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|