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| Product Name | NFATC2, 396-678aa, Human, His-tag, Baculovirus |
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| Description | Purity: > 90% by SDS - PAGE Format: Liquid. In Phosphate Buffered Saline (pH 7.4) containing 40% glycerol, 1mM DTT.. NFATC2, also known as nuclear factor of activated T-cells cytoplasmic 2 isoform C, is a member of the nuclear factor of activated T cells family. This protein plays a vital role in the course of T helper cell activation, differentiation, and effector function. Although KO of an individual NFAT isoform in T cells leads to rather mild effects, T cells deficient for NFATC1 and 2 completely fail to produce T helper cell effector cytokines, such as the interleukins IL-2 and IL-4 or interferon gamma. Also, it is highly phosphorylated and retained in the cytoplasm. Following T cell receptor (TCR) stimulation, dephosphorylation by calcium-activated calcineurin induces a conformational change of NFATC2 that exposes one or more nuclear localization sequences. Recombinant human NFATC2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
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| Size | 100ug, 20ug, 4ug |
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| Concentration | n/a |
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| Applications | SDS-PAGE |
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| Other Names | Nuclear factor of activated T-cells cytoplasmic 2 isoform C, NFATC2, NFAT1, NFATP |
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| Gene, Accession, CAS # | NP 775114 |
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| Catalog # | ATGP3772 |
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| Order / More Info | NFATC2, 396-678aa, Human, His-tag, Baculovirus from ATGen |
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| Product Specific References | n/a |
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