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| Antigenic Specificity | Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | TNF-alpha is an important cytokine produced by numerous cell types including neutrophils, activated lymphoctyes, macrophages an NK cells. It plays a critical role in inflammatory responses and in apoptosis . TNF-alpha exists as a membrane-anchored and soluble form, both of which show biological activity. Response to TNF-alpha is mediated through two receptors, TNF-R1, which is widely expressed, and TNF-R2, which is expressed mainly in immune and endothelial cells . Antagonists to TNF-alpha have been validated as therapeutic targets for rheumatoid arthritis and other immune disorders . The two receptors for TNF-alpha, TNF-R1 (55 kDa) and TNF-R2 (75 kDa) can mediate distinct cellular responses . In most cases cytotoxicity elicited by TNF has been reported to act throught TNF-R1 . In contrast, TNF-R2 appears to be important in T cell signaling and responses to infection . TNF-R2 binds to distinct members of the TRAF family leading to the activation of NF-kappaB . Soluble forms of both receptors have also been characterized which can bind TNF-alpha and may play an important role in immune disorders . Synonyms: TNFRSF1B,CD120b,TBPII,TNF-R-II,TNF-R75,TNFBR,TNFR1B,TNFR2,TNFR80,p75,p75TNFR , |
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| Immunogen | Recombinant protein of human TNFRSF1B |
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| Other Names | MGC83471|LOC100218184|TRAF2|TANK|TNF-RII/TNFRSF1B|TNFRSF1B|CD120b|TBPII|TNF-R-II|TNF-R75|TNFBR|TNFR1B|TNFR2|TNFR80|p75|p75TNFR|TNF-R2|TNF-alphaR2|TNFRII|TNFalpha-R2|Tnfr-1|Tnfr2|TNFR-II |
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| Gene, Accession # | Gene ID: 7133,21938,156767 |
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| Catalog # | ABIN1684059 |
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| Price | |
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| Order / More Info | Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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