| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | CD180 Molecule (CD180) |
|---|
| Clone | G28-8 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG1 |
|---|
| Format | unconjugated |
|---|
| Size | 0.1 mg |
|---|
| Concentration | n/a |
|---|
| Applications | Flow Cytometry (FACS),Functional Studies (Func),Immunoprecipitation (IP) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | CD180, also known as RP105 (or Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1 , and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size. |
|---|
| Immunogen | Human tonsillar B cells |
|---|
| Other Names | Ly78|CD180|LY64|RP105|F630107B15 |
|---|
| Gene, Accession # | Gene ID: 4064 |
|---|
| Catalog # | ABIN2749219 |
|---|
| Price | |
|---|
| Order / More Info | CD180 Molecule (CD180) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|