| 产品详情 |
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| Product Name | Embelin |
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| Description | Purity >98% by HPLC. Antitumour, antiinflammatory and analgetic agent. Specifically antagonizes XIAP (X-linked inhibitor of apoptosis)-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50 = 4.1 µM in a competitive binding assay with Smac peptide). Selectively induces caspase-9-mediated apoptosis in prostate cancer cells with high levels of XIAP (IC50 = 3.7 and 5.7 µM for PC-3 and LnCap respectively), while exhibiting much less effect towards cells with low level XIAP (IC50 = 19.3 and 20.1 µM for WI-38 and PrEC respectively). Also shown to sensitize XIAP overexpressing Jurkat cells to Etoposide-induced apoptosis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione |
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| Gene, Accession, CAS # | CAS: 550-24-3 |
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| Catalog # | LS-H11068 |
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| Price | |
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| Order / More Info | Embelin from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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