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| Product Name | CXCL12, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). A member of the CXC chemokine family, CXCL12 is strongly chemotactic for T-, B-, and cancer cells. Known to exert its effects mainly through binding to the CXCR4 receptor, CXCL12 plays an important role in morphogenesis, angiogenesis, and cancer metastasis. CXCL12 also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for CXCL12. Encoded by a single gene, SDF-1 alpha (89aa) and SDF-1 beta (93aa) are derivatives of an alternative splicing event. SDF-1alpha and SDF-1beta have identical amino acid sequences, differing only, by the presence of four extra amino acids at the C-terminal of the beta form. SDF-1 beta is constitutively expressed by stromal cells. Source: Recombinant protein corresponding to human CXCL12 expressed in E. coli. Molecular Weight: ~8.5kD Biological Activity: Determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentration range of 5.0-40ng/mL. Endo |
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| Size | 10ug, 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CXCL12, Recombinant, Human (Stromal Cell-Derived Factor 1, SDF-1, hSDF-1, C-X-C Motif Chemokine 12, Intercrine Reduced in Hepatomas, IRH, Pre-B Cell Growth-Stimulating Factor, PBSF, Cell-Derived Factor-1 Beta, SDF-1 Beta) |
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| Gene, Accession, CAS # | SwissProt: P48061 |
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| Catalog # | 499910 |
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| Order / More Info | CXCL12, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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