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| Product Name | Recombinant Human E3 ubiquitin-protein ligase MIB1 |
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| Description | MW: 43 KD. Purity 90%. E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis |
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| Size | 0.05 mg, 0.2 mg, 0.5 mg, 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Recombinant human E3 ubiquitin-protein ligase MIB1 protein] |
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| Gene, Accession, CAS # | MIB1; MIB; DIP1; ZZZ6; DIP-1; LVNC7; ZZANK2, Gene ID: 57534 |
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| Catalog # | MBS955619 |
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| Order / More Info | Recombinant Human E3 ubiquitin-protein ligase MIB1 from MYBIOSOURCE INC. |
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| Product Specific References | [1] Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. |
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