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| Product Name | Recombinant Human E3 ubiquitin-protein ligase MYLIP |
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| Description | 1-445aa; Full Length. MW: 77.3kD. Purity >90% as determined by SDS-PAGE. E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. A |
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| Size | 0.01 mg (Yeast), 0.01 mg (E-Coli), 0.05 mg (Yeast), 0.05 mg (E-Coli), 0.1 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Inducible degrader of the LDL-receptor; Idol; Myosin regulatory light chain interacting protein; MIR] |
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| Gene, Accession, CAS # | MYLIP, Gene ID: 29116, Accession: NP_037394.2 |
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| Catalog # | MBS1438356 |
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| Order / More Info | Recombinant Human E3 ubiquitin-protein ligase MYLIP from MYBIOSOURCE INC. |
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| Product Specific References | MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.Olsson P.-A., Korhonen L., Mercer E.A., Lindholm D.J. Biol. Chem. 274:36288-36292(1999) |
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